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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
APP
All Species:
32.73
Human Site:
Y115
Identified Species:
65.45
UniProt:
P05067
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P05067
NP_958817.1
770
86943
Y115
H
P
H
F
V
I
P
Y
R
C
L
V
G
E
F
Chimpanzee
Pan troglodytes
Q5IS80
770
86953
Y115
H
P
H
F
V
I
P
Y
R
C
L
V
G
E
F
Rhesus Macaque
Macaca mulatta
XP_001104599
750
84778
Y115
H
P
H
F
V
I
P
Y
R
C
L
V
G
E
F
Dog
Lupus familis
XP_856325
785
88788
C133
H
V
V
V
P
F
K
C
L
V
G
E
F
V
S
Cat
Felis silvestris
Mouse
Mus musculus
P12023
770
86704
Y115
H
T
H
I
V
I
P
Y
R
C
L
V
G
E
F
Rat
Rattus norvegicus
P08592
770
86686
Y115
H
T
H
I
V
I
P
Y
R
C
L
V
G
E
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_989639
751
84687
Y115
H
P
H
I
V
V
P
Y
R
C
L
V
G
E
F
Frog
Xenopus laevis
NP_001082098
749
84748
Y114
R
T
H
I
V
V
P
Y
R
C
L
V
G
E
F
Zebra Danio
Brachydanio rerio
NP_571639
738
83559
Y116
H
M
H
I
V
V
P
Y
R
C
L
V
G
E
F
Tiger Blowfish
Takifugu rubipres
O93279
737
82838
Y116
H
T
H
I
V
V
P
Y
R
C
L
V
G
E
F
Fruit Fly
Dros. melanogaster
P14599
887
98314
I123
C
K
G
S
H
R
W
I
K
P
F
R
C
L
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10651
686
79416
H118
T
H
S
V
R
P
Y
H
C
I
D
G
E
F
H
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
94.9
50.7
N.A.
96.6
96.8
N.A.
N.A.
91.8
84.8
69.7
67.2
26.2
N.A.
23.6
N.A.
Protein Similarity:
100
99.8
95.7
66.7
N.A.
97.5
97.9
N.A.
N.A.
94
90.9
80.5
78.9
41.5
N.A.
42.2
N.A.
P-Site Identity:
100
100
100
6.6
N.A.
86.6
86.6
N.A.
N.A.
86.6
73.3
80
80
0
N.A.
0
N.A.
P-Site Similarity:
100
100
100
6.6
N.A.
86.6
86.6
N.A.
N.A.
93.3
80
86.6
86.6
6.6
N.A.
6.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
9
0
0
0
0
0
0
9
9
75
0
0
9
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
9
9
75
0
% E
% Phe:
0
0
0
25
0
9
0
0
0
0
9
0
9
9
75
% F
% Gly:
0
0
9
0
0
0
0
0
0
0
9
9
75
0
9
% G
% His:
75
9
75
0
9
0
0
9
0
0
0
0
0
0
9
% H
% Ile:
0
0
0
50
0
42
0
9
0
9
0
0
0
0
0
% I
% Lys:
0
9
0
0
0
0
9
0
9
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
9
0
75
0
0
9
0
% L
% Met:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
34
0
0
9
9
75
0
0
9
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
9
0
0
0
9
9
0
0
75
0
0
9
0
0
0
% R
% Ser:
0
0
9
9
0
0
0
0
0
0
0
0
0
0
9
% S
% Thr:
9
34
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
9
9
17
75
34
0
0
0
9
0
75
0
9
0
% V
% Trp:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
9
75
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _